All enrolled subjects will receive vitamin D3 at 4,000 IU daily for approximately one year.

Enrolled subjects will supplement with vitamin D3 at 4,000 IU daily for one year

cholecalciferol

RNA-seq analysis will be used to (a) identify changes in transcriptional profiles and biological pathways in the prostate between African American and Caucasian men and (b) compare Allostatic Load results to determine stress response and (c) identify changes in the molecular signature in relation to vitamin D levels

Standard of Care Prostate Biopsy - collection of 13th core for RNA-seq

Pathology results of the prostate biopsies will be analyzed for changes in the (a) Gleason Score (b) the number of positive cores (0 to 12) and (c) the highest percentage of positive core involvement (0 to 100%).

Standard of Care Prostate Biopsies at baseline and after one year vitamin D3 supplementation

Diagnostic Test: Allostatic Load Measurements at baseline and after one year vitamin D3 supplementation Allostatic Load measurements to determine body stress compared at baseline and after one year of vitamin D3 supplementation. Also compared with RNA-seq results to determine stress response.

Other Names:

Bloodwork for HgbA1c, lipid profile, creatinine, albumin and vitamin D levels. Body measurements: Ht. Wt, BMI, waist and hip measurements for waist/hip ratio. Measurements of systolic and diastolic blood pressure and heart rate

Allostatic Load

Individuals having a prostate biopsy are eligible for recruitment.

콜레칼시페롤, 표준 전립선 생검 - RNA-seq를 위한 13번째 코어 수집, 기준선 및 비타민 D3 보충 1년 후 표준 전립선 생검, 알로스테틱 부하