ALS 및 PLS 환자의 얼굴 통증 감소와 턱 운동 개선을 위한 비침습 전기 자극의 효과를 평가하는 초기 시험입니다.

All 10 participants will receive a single TENS intervention, with electrodes placed over the masseter and TMJ regions. This intervention is designed to evaluate TENS as a potential treatment for reducing facial pain and improving jaw mobility and chewing function in individuals with ALS and PLS..

TENS intervention will be administered using a current-controlled TENS device that produces charge-balanced, symmetrical biphasic rectangular pulses. Participants will be seated and skin cleaned prior to applying 2 self-adhesive round surface electrodes (25mm) on each side of the face. One electrode (anode) will be placed over the masseter muscle belly, while the other (cathode) will be positioned over the TMJ. Electrode placement will be confirmed by palpation of the TMJ and Masseter. This set up will be mirrored on the opposite side. Once all 4 electrodes are in place, the TENS unit will be turned on.

Participants will remain seated. The TENS unit will be set to manual mode to deliver the stimulation at a frequency of 50 Hertz (Hz) and a pulse width of 200 microseconds (µseconds). Stimulation amplitudes will be gradually increased from 0 milliamps (mA) to each participant's tolerance level. The 30 minute TENS intervention will then take place.

Transcutaneous Electrical Nerve Stimulation to reduce facial pain and improve jaw range of motion in ALS and PLS

참가자 10명 전원은 교근과 턱관절(TMJ) 부위에 전극을 부착하는 단일 TENS 시술을 받게 됩니다. 이 시술은 ALS 및 PLS 환자의 안면 통증 완화, 턱 가동성 및 저작 기능 개선을 위한 잠재적 치료법으로서 TENS의 효과를 평가하기 위해 고안되었습니다.

ALS 및 PLS 환자의 얼굴 통증을 줄이고 턱 운동 범위를 개선하기 위한 경피적 전기 신경 자극

Kayla Chomko, PT, DPT

Raquel Garcia, SLP.D, CCC-SLP, BCS-S

운동 뉴런 질환이 있는 환자의 얼굴 통증, 턱 움직임 및 구강 건강에 대한 전기 자극의 영향을 조사합니다.

Mode of Group Serum application : On-site single use

Standard cleanser + Investigational Serum (random half-face) \[FLA #2039128 50\]

- subjects should wash face with standard cleanser \[FLA #730457 36\] on site before measurements.

The technician will apply the Investigational Serum \[FLA #2039128 50\] on the subject's half face (according to the Annex 11.6) at the test site, keep another half face as blank control.

Investigational Serum, Standard Cleanser

Infrared light has high radiation frequency, its permeability is strong, the wavelength of infrared light can penetrate the human dermis to promote blood circulation and induce skin redness.The redness induction process will be done after baseline measurements for each subject.The subject's face was exposed at a distance of 20cm from infrared lamp for minimum 5 - 10 minutes at a temperature of 30-40°C and a wavelength of 760-5000 nm. In general, the skin will not be burned during the induction process. Due to individual differences, if the subjects cannot tolerate or feel uncomfortable during the process, the investigators will stop the process according to the situation; If there is any burn during the process, the on-site dermatologist will treat it in time, and the subject needs to follow the dermatologist's advice for follow-up treatment.

Infrared light type: PHILIPS, IR250 RH IR2, 230-250V, 250W, wave length 760-5000nm, T 30\~40°C

운동 뉴런 질환이 있는 환자의 얼굴 통증, 턱 움직임 및 구강 건강에 대한 전기 자극의 영향을 조사합니다.

조사용 세럼, 표준 클렌저, 얼굴 발적 유도를 위한 적외선