Participants will participate in 8 weekly sessions.

Components include:

* education on the co-occurrence of mental and physical problems
* goal setting for health behavior change
* self-monitoring

HEP is an active control condition for mind body programs and is structurally equivalent to SMART3RP

8 weekly sessions that include education on the co-occurrence of mental and physical problems, goal setting for health behavior change, and self-monitoring. Each session includes basic didactic information, interactive application of the information, and open discussion of didactic material.

Health Education Program

Participants will participate in 8 weekly sessions.

The intervention components include:

* Eliciting the relaxation response (RR),
* CBT strategies to improve stress management
* Positive psychology strategies to achieve growth enhancement

The SMART3RP-lymphoma is a group program that, through a variety of mind-body approaches, such as imagery, relaxation, and yoga, seeks to buffer stress and promote psychological resiliency and physical well-being.

SMART3RP-Lymphoma

Giselle K Perez, PhD

Participants randomized to EUC will be referred to their site social work team. This most closely resembles the real-world care available to survivors on an outpatient basis. It is an enhanced version of usual care because proactive identification and referral of posttreatment survivors is not routinely done.

Participants will receive a singleevaluation with a site social worker along with a list of mental health, social or community resources . This most closely resembles the real-world care available to survivors on an outpatient basis, however, we call this enhanced usual care since proactive identification and referral of posttreatment survivors is not routinely done.

Enhanced Usual Care

Participants will participate in 8 weekly group sessions, delivered virtually. The intervention components include: 1. Eliciting the relaxation response (RR) involves sustained mental focus with an attitude of open receptive awareness. 2. CBT to improve stress management involves increasing awareness and identification of the components of one's stress response (negative thoughts, emotions, physical reactions, behaviors, and relational) and learning skills at each session to alter these components (e.g., cognitive restructuring). 3. Positive psychology strategies to achieve growth enhancement focus on utilizing techniques and skills to promote positive growth. Skills focus on increasing social support, positive affect, and compassion.

The intervention components include: 1. Eliciting the relaxation response (RR) involves sustained mental focus with an attitude of open receptive awareness. 2. CBT to improve stress management involves increasing awareness and identification of the components of one's stress response (negative thoughts, emotions, physical reactions, behaviors, and relational) and learning skills at each session to alter these components (e.g., cognitive restructuring). 3. Positive psychology strategies to achieve growth enhancement focus on utilizing techniques and skills to promote positive growth. Skills focus on increasing social support, positive affect, and compassion.

Giselle Perez, PhD

Blood samples will be collected :

* at baseline (before the 1st R-CHOP cycle)
* before the 3d administration of chemotherapy (CT) (i.e. after 2 cycles of CT and same timepoint as interim FDG-PET/CT)
* after the 4th administration of the CT
* at the end of induction (i.e. end of R-CHOP treatment)
* at 24 months after initiation of R-CHOP treatment
* at the time of progression (if progression occurs before 24 months of treatment).

Tumor samples will be collected at baseline (from an archived initial diagnostic tumor specimen) and at the time of progression (if applicable from lymph node biopsy performed as part of a standard of care surgical procedure).

Bone marrow samples will be collected at baseline and at the time of progression (if applicable) only in patients for whom a bone marrow aspiration (BMA) is necessary as part of their standard of care, upon physician's decision.

건강 교육 프로그램, SMART3RP-림프종

향상된 일반 치료, SMART3RP-림프종

조직학적으로 미만성 거대 B세포 림프종이 확진된 환자로, 1차 치료로 R-CHOP 요법이 계획되어 있습니다.