A supervised 12-week cycling-based aerobic exercise intervention performed twice per week.

Exercise

handgrip and treadmill walking 4 days per week

6 weeks of exercise training (Pre-training)

6 weeks of exercise training (Post-training)

Jill Slade, PhD

Katharine Currie, PhD

Healthy volunteers will undergo RHC while exercising and an optional muscle biopsy.

A procedure to measure how well or poorly your heart is pumping and to measure the pressures in the heart and lungs. A catheter will be inserted into a vein and artery in order to take the measurements and this will be conducted while exercising on a supine cycle ergometer. Various measurements will be taken during periods of rest and exercise.

Right Heart Catheterization (RHC) while exercising

A sample of muscle tissue will be collected and analyzed for the ability of the cells to utilize oxygen.

Optional Muscle Biopsy

Patients diagnosed with PAH-ILD will undergo RHC while exercising, receive inhaled treprostinil, and undergo an optional muscle biopsy.

30mcg (5 breaths) of inhaled treprostinil will be administered during the RHC procedure and patients will be initiated on outpatient inhaled treprostinil therapy for 3-months with gradual up titration to target dose as per standard clinical practice.

Treprostinil

Temporary target during an anaerobic training session

SmartGuard during an anaerobic training session

Maria M Manrique

Ana M Gómez, Endocrinologyst

Receive tele-exercise training and undergo pulmonary function testing and exercise testing

Tele-exercise

Pilates exercises, particularly those focusing on core stability, balance, and flexibility, are highly beneficial for individuals at risk of falls. These exercises enhance proprioception, which is the body's ability to sense movement, action, and location, thereby improving coordination and balance. For example, exercises like the "Single Leg Stretch" and "Roll-Up" target the abdominal muscles, which are crucial for maintaining stability. Additionally, "Leg Circles" and "Side Planks" help strengthen hip abductors and stabilizers, contributing to better postural alignment and reducing the likelihood of falls. By regularly incorporating Pilates into a fitness routine, individuals can build strength and confidence, ultimately helping to prevent falls and maintain independence.

pilates

Exercise phase Training Time Warm-Up Gentle, dynamic stretches focusing on the spine, hips, and legs. Gently roll the head from side to side to release tension, Move shoulders in a circular motion to loosen muscles, While standing, rotate the torso gently from side to side, Rotate each ankle in both directions to improve mobility. 5 minutes Core Activation Using pulley rope system the Arch and Curl, to engage the abdominal muscles, Focus on maintaining proper alignment and breathing deeply. 13 minutes Balance and Coordination Using pulley rope system Standing Series, shifting weight, such as the Spiral Sequence, to improve coordination. 12 minutes Flexibility and Range of Motion Leg stretches using the Leg Extension Unit to improve hip and knee range of motion. 5 minutes

gyrotonic expansion exercise

Ahmed M Elfahl, phd

This group will receive basic body awareness training

Basic body awareness training will be applied to preschool children in terms of motor development and body perception

body awareness therapy

An obstacle course will be set up for this group and play-based exercise methods will be implemented.

Play-based exercise training will be implemented for preschool children by designing games that they enjoy playing, in order to support motor development and body perception.

play-based exercise

harran lecturer

Participants will receive a theory-based, remotely-delivered exercise training program that includes aerobic and resistance exercise training.

The intervention group will be encouraged to complete aerobic and resistance training exercises three times a week, and either at home, in the community (e.g., park, shopping mall), or any suitable environment of the participant's choice. Exercise equipment for monitoring walking and complete resistance training will be provided to the intervention group. The exercise training prescription involves 30+ minutes of moderate-intensity walking (≥100 steps/min) monitored by a waist-worn pedometer, and resistance training consisting of 1-2 sets, 10-15 repetitions of 5-10 exercises targeting lower and upper body, and core muscle groups using elastic bands.

Exercise Training Program

Participants will receive a remotely-delivered flexibility program, focusing on improving flexibility and range of motion.

The control group will be encouraged to complete stretching and range of motion exercises three times a week, and either at home, in the community (e.g., park, shopping mall), or any suitable environment of the participant's choice. Exercise equipment (yoga mat) for monitoring walking and complete flexibility training will be provided to the control group. The flexibility training prescription involves stretches from the Stretching for People with MS: An Illustrated Manual from the National MS Society.

Flexibility Program

Intervention group that receive 30 min exercise training twice weekly in 20 weeks

Exercise training with aerobic and strength training, 30 min per session

Exercise training

Stig Molsted, PhD

Stig Moelsted, PhD

The protocol will be comprised of up to 15 exercise sessions over the course of participants' 5-6 weeks radiation treatment period with each session lasting up to 60 minutes. Exercise sessions are a combination of resistance, aerobic, and flexibility training using bodyweight and/or elastic bands for resistance.

Study participants will engage in 7-10 exercises per session targeting major muscle groups (e.g. quadriceps, hamstrings, glutes, back, chest, arms, abdominal muscles). Movements will alternate between the lower and upper body thus allowing ample time for muscle-group recovery between exercises.

Kathrin Milbury, MA,PHD

Patients receive fisetin PO on days 1-3 of each cycle. Treatment repeats every 14 days for 8 cycles in the absence of disease progression or unacceptable toxicity. Patients also receive handout on the importance of physical activity during baseline. Patients undergo collection of blood samples on study.

Biospecimen Collection

Educational Intervention

Fisetin

Physical Performance Testing

Quality-of-Life Assessment

Questionnaire Administration

Patients receive fisetin PO on days 1-3 of each cycle. Treatment repeats every 14 days for 8 cycles in the absence of disease progression or unacceptable toxicity. Patients also receive individually tailored supervised exercise training consisting of 30-45 minutes of aerobic training and 20-30 minutes of resistance training three times a week over 16 weeks. Patients undergo collection of blood samples on study.

Receive individually tailored exercise intervention

Exercise Intervention

Patients receive placebo PO on days 1-3 of each cycle. Treatment repeats every 14 days for 8 cycles in the absence of disease progression or unacceptable toxicity. Patients also receive individually tailored supervised exercise training consisting of 30-45 minutes of aerobic training and 20-30 minutes of resistance training three times a week over 16 weeks. Patients undergo collection of blood samples on study.

Placebo Administration

Patients receive placebo PO on days 1-3 of each cycle. Treatment repeats every 14 days for 8 cycles in the absence of disease progression or unacceptable toxicity. Patients also receive handout on the importance of physical activity during baseline. Patients undergo collection of blood samples on study.

Mina S. Sedrak, MD

Mina S. Sedrak

Mina S. sedrak, MD

All participants will complete one, 60-minute bout of stationary cycling

Exercise Mode

All participants will complete one, 60-minute bout of treadmill walking

Participants randomized in this group will be asked to use the app for 12 weeks. Participants will be ask to preferably spread each exercise session over different days of the week. While exercise equipment is not required, the app includes options for using elastic resistance bands or dumbbells. Following baseline assessment and randomization, participants in the intervention group will receive a brief instructional video on how to download and use the app, along with access to a website offering support materials, guidelines, and additional instructional videos. All participants will complete questionnaires at baseline, 12 weeks (post-intervention), and 3 months follow-up.

Participants will be asked to use a cancer-specific exercise mobile app for 12 weeks. The program is designed to achieve the goal of exercising for at least 90 minutes per week, including aerobic exercise three times a week and resistance training twice a week. While exercise equipment is not required, the app supports the optional use of an elastic resistance band or a pair of dumbbells. The app comes with various features to support the exercise journey. Participants will be able to track their progress through periodic testing, access a library of resources that includes information on exercise, and log any additional workouts they perform outside the app. The exercise prescription will be tailored to daily fatigue levels that will be rated before each workout. This ensures that the program is customized to meet individual needs and abilities.

This group will received the ACSM exercise guidelines.

Kerry Courneya, PhD

Miriam Fillion

4 mg qd titrated to 8 mg qd perindopril + aerobic exercise

Twice weekly centered based aerobic exercise + 3/week home-based walking

Aerobic exercise

Perindopril

50 mg qd titrated to 100 mg qd losartan + aerobic exercise

Losartan

12.5 mg qd titrated to 25 mg qd HCTZ + aerobic exercise

HCTZ

The participants receive a twelve weeks of a supervised physical exercise program, based on aerobic and strength training.

The intervention include a personalized physical exercise program based on aerobic and strength training, with prior warm-up and post cool-down exercises. International/national exercise prescription guidelines will be applied for each clinical condition (cardio/cerebrovascular disease/risk, diabetes mellitus and osteoarthritis).

Physical Exercise

Participants do not receive any intervention.

Associação para o Desenvolvimento do Centro Académico de Investigação e Formação Biomédica do Algarv

All patients recruited in general practice are asked to fill out a patient questionnaire and examined:

- Collenbrander Mixed contrast card: testing near vision binocularly at 40 cm, using both 100% and 10% contrast.

- Amsler Test: Conducted for both eyes to check for central vision issues.

- Visual Field Test: Performed using the Donders method to assess peripheral vision, conducted for both eyes.

After tests in general practice, all patients undergo a comprehensive vision assessment at local optician shops, which include the following tests:

* Habitual Vision Testing: Near and distance vision with habitual glasses.
* Best Corrected Distance Vision: Monocular and binocular.
* Intraocular Pressure Measurement Assessed using air tonometry or Icare.
* Ocular Imaging: 3D peripapillary and macula optical coherence tomography (OCT) scans, and fundus photography.

A project ophtalmologist analyze patient-data from optometrists.

GP or GP nurse carry out the three vision tests. All patients visit optician shop collaborating with the project. An ophthalmologist review data from optometrists and provide an epicrisis to general practice. In case of acute conditions, the ophthalmologist is responsible for expedient treatment. If the patient needs further control by ophthalmologist within 12 month waiting time, general practice are responsible for referring the patient.

focus on vision impairment in older patients in general practice

Louise Uhre

Mads Kristensen

Patients and caregivers receive Walking for Recovery from Surgery prehabilitation intervention in 4 sessions 3-7 days before surgery, before discharge, and at 2 and 7 days post-discharge.

Receive Walking for Recovery from Surgery prehabilitation intervention

Survey Administration

Starting at least 4 weeks prior to date of surgery, patients use the ExerciseRx app to follow the (P)REHAB exercise program, which consists of four 20-30 minute home exercise sessions per week and personalized step count goal setting and tracking, while receiving SOC chemotherapy, if applicable, prior to SOC surgery and for 90 days following surgery (total \~4-7 months). Patients also download the FitBit app and wear a FitBit throughout the study.

App-Based Intervention

Interview

Wearable Activity Tracker

Patients receive SOC educational materials and, starting at least 4 weeks prior to date of surgery, patients wear a FitBit and use the FitBit app while receiving SOC chemotherapy, if applicable, prior to SOC surgery.

Best Practice

Get Moving Research Coordinator

Sarah Psutka

Participants in this group receives a 12-week structured exercise program delivered synchronously twice per week through live online video sessions (Google Meet or WhatsApp). Each session lasts approximately 40 minutes and included 10 minutes of warm-up, 25 minutes of strengthening and core stabilization exercises, and 5 minutes of cool-down stretching. All sessions are supervised in real time by a physiotherapist.

The program focuses on improving functional capacity, muscle strength, fatigue, independence, and quality of life in individuals with relapsing-remitting multiple sclerosis.

Participants receive a 12-week structured combined exercise program delivered twice weekly via live online video sessions (Google Meet or WhatsApp). Each session lasts approximately 40 minutes and included 10 minutes of warm-up, 25 minutes of strengthening and core stabilization exercises, and 5 minutes of cool-down stretching.

Exercise intensity is maintained between 12 and 15 on the Borg Rating of Perceived Exertion scale. Rest periods are adjusted individually. Exercises are supervised in real time by a physiotherapist, who monitored participants' form, safety, and perceived fatigue throughout each session

Combined Exercise Program (Synchronous Delivery)

Participants in this group receives the same 12-week structured exercise program delivered asynchronously through pre-recorded videos shared online twice per week. Each session lasts approximately 40 minutes, including warm-up, main strengthening/core exercises, and cool-down.

Participants maintain exercise logs and reported adherence weekly. Physiotherapists monitor logs and provided feedback via e-mail or phone as needed. The program targets the same outcomes as the synchronous intervention.

Participants follow the same 12-week structured exercise program twice weekly using pre-recorded instructional videos. The program consists of warm-up, strengthening/core, and cool-down components identical to the synchronous arm.

Participants receive detailed guidance to ensure correct posture and performance, logged each session in exercise diaries, and submitted weekly feedback to researchers. Investigators review exercise logs and provided individualized feedback via e-mail or phone. In case of difficulties, participants can contact the research team for assistance

운동

6주간의 운동 훈련(Pre-training), 6주간의 운동 훈련(Post-training)

트레프로스티닐, 운동 중 우심장 카테터 도관술(RHC), 선택적 근육 생검

무산소 운동 훈련 세션 중 임시 목표, 무산소 운동 훈련 세션 중 SmartGuard

원격 운동

필라테스, 자이로토닉 확장 운동

신체 인식 치료, 놀이 기반 운동

운동 훈련 프로그램, 유연성 프로그램

운동 훈련

운동

운동

생체 시료 채취, 교육적 중재, 운동 중재, 피세틴, 신체 성능 검사, 위약 투여, 삶의 질 평가, 설문지 투여

운동 모드

운동

유산소 운동, 페린도프릴, 로사르탄, HCTZ

신체 운동

일반 진료에서 노인 환자의 시력 장애에 초점을 맞추다

운동 중재, 삶의 질 평가, 설문 조사 관리

모범 사례, 운동 중재, 앱 기반 중재, 앱 기반 중재, 인터뷰, 웨어러블 활동 추적기, 신체 성능 검사, 설문지 관리

복합 운동 프로그램(동기식 전달), 복합 운동 프로그램(비동기식 전달)