Irreversible electroporation (IRE) is a procedure which involves the passage of short intense electrical pulses between probes to destabilize cell membranes by creating "nanopores" which leads to cell destabilisation and cell death.

IRE can be used to selectively damage cancerous cells whilst sparing adjacent supporting connective tissue in vessels and bile ducts allowing a more targeted treatment compared to other types of ablation. IRE also avoids the heat-sink phenomenon which compromises the effectiveness of thermal ablation and possibly reduces the risks of biliary injury.

Irreversible Electroporation

Ajith Siriwardena, MD FRCS

Sonic activation of irrigation with Eddy system

Root canal treatment in primary molars with irreversible pulpitis followed by coronal restoration with stainless-steel crowns in a single visit.

Root canal treatment in primary molars with irreversible pulpitis

sonic activation of irrigation with EDDY system during root canal treatment in primary molars

EDDY system for sonic activation of irrigation

Irrigation with side-vented needle without activation

conventional irrigation with side-vented needle without activation during root canal treatment in primary molars

side-vented needle

All patients enrolled in this trial will receive IRE treatment with the NanoKnife System.

Irreversible Electroporation (IRE) using NanoKnife technology uses high voltage current pulses via probes placed around the prostate tumour via the perineum. The electricity damages the cell membranes rendering the cells dead. Hypothesized benefits of IRE over other focal therapy options include the ability to treat large or small lesions. Also, because the technology spares vessels, it can be used to treat prostate areas adjacent to sensitive structures (ie prostate apex near the sphincter and lateral peripheral zone near the neurovascular bundle). Finally, treatments take approximately 1-1.5 hours, thus the technology could be used to treat several patients per day.

Irreversible Electroporation (NanoKnife)

Nathan Perlis, MD

Participants will undergo irreversible electroporation (IRE) using the NanoKnife system. About 1 week following IRE, study participants will receive a 200mg dose of pembrolizumab.

Pembrolizumab is an immunotherapy that will be administered via IV infusion.

Pembrolizumab

Participants will undergo IRE as standard of care treatment.

H. Lee Moffitt Cancer Center and Research Institute

Conventional pancreaticoduodenectomy without prior isolation of the SMA; antero-posterior approach of the uncinate process after pancreatic section.

SMA-first pancreaticoduodenectomy using either right posterior or anterior approach. SMA identified and isolated with peri-adventitial dissection before any irreversible section.

Before any irreversible gesture, the surgeon identifies and isolates the superior mesenteric artery and dissects nerve plexus and nodes on the right side up to the SMA origin (right posterior or anterior approach).

비가역적 전기천공법

비가역적 치수염이 있는 유치구치의 근관치료, 관개의 음파 활성화를 위한 EDDY 시스템, 측면 통풍 바늘

비가역적 전기천공법

비가역적 전기천공법(나노나이프)

펨브롤리주맙, 비가역적 전기천공법