Participants in the AIH First arm will undergo 5 days of Acute Intermittent Hypoxia Interventions. Following the 5 Days of AIH, after a 2-week washout period, this group will then undergo 5 days of Sham AIH Interventions. The procedures are identical to AIH but with 21% oxygen for both breath cycles

During each AIH session, the participant will be equipped with a non-rebreathing face mask, and provided with the AIH intervention. The AIH intervention involves alternating breathing cycles: one with lower oxygen concentration (9-10% Oxygen) than that at sea level (\~21% Oxygen) lasting between 30 and 60 seconds, followed by a similar duration of normal room air (21% Oxygen). This cycle will be repeated 15 times in one session, continuous blood oxygen levels and heart rate will be monitored.

Acute Intermittent Hypoxia

During each Sham-AIH session, the participant will be equipped with a non-rebreathing face mask, and provided with the Sham-AIH intervention. The Sham-AIH intervention involves alternating breathing cycles: both with oxygen concentrations of \~21% Oxygen lasting between 30 and 60 seconds, followed by another similar duration of normal room air (21% Oxygen). This cycle will be repeated 15 times in one session, continuous blood oxygen levels and heart rate will be monitored.

Sham-Acute Intermittent Hypoxia

Participants in the Sham First arm will undergo 5 days of Sham-Acute Intermittent Hypoxia Interventions. Following the 5 Days of Sham-AIH, after a 2-week washout period, this group will then undergo 5 days of AIH Interventions. The procedures are identical to Sham-AIH but with 9-10% oxygen for the first breath cycle

Alexander Barry, MS, CCRC

Milap Sandhu, PT, PhD

Molly Bright, D.Phil.

* 1st palliative care visit within 30 days of randomization in the outpatient or hospital
* In outpatient setting: once monthly palliative care visits (or video/ or phone)
* During hospital admissions: At least twice weekly palliative care visits

Specialized medical care for people with serious illness. This type of care is focused on providing relief from the symptoms and stress of a serious illness. The goal is to improve quality of life for both the patient and the family

Palliative Care

Standard Leukemia care

* Palliative care consults only upon request
* Standard oncology care

Participants randomized to usual care will receive preprinted discharge instructions on HTN and a 48-72-hour referral to our FQHC (or other community health center if pre-assigned though Illinois Medicaid) to schedule their follow-up appointment (current standard of care)

Participants receive:

1. HTN Educational Video about high BP, how it is diagnosed, and importance of treatment to prevent secondary complications.
2. Visual Echocardiogram Image Clips of age/gender-matched echocardiograms will be used to educate and motivate patients to change behavior and improve their BP.
3. Mobile Health and Remote BP monitoring- participants receive an FDA-approved home blood pressure monitoring (HBPM) kit that includes the Nokia wireless BPM+ monitor and Health Mate mobile app. The app automatically launches when the patient slips on the cuff. Synced data are automatically uploaded from the mobile app to the iCardia server of our study.
4. A Post-Acute Care HTN Transition consultation (PACHT-c) with a clinical pharmacist or advanced practice nurse (APN).

The video will educate participants in arm 2 about high BP, how it is diagnosed, and the importance of treating it to prevent secondary complications.

HTN Educational Video

Visual clips of age/gender-matched echocardiograms will be used to educate and motivate patients to change their behavior and improve their BP. We have found that real time visualization of cardiac ultrasound images with active discussion of findings is a significant patient motivator and empowerment tool, and was a significant factor in the success of our previous pilot study.

Visual Echocardiogram Image Clips

All participants randomized to the intervention group will receive an FDA-approved HBPM kit that includes the Nokia wireless (self-inflating) BPM+ monitor and Health Mate mobile app. The app automatically launches when the patient slips on the cuff and turns on the monitor to measure his/her BP. Synced data are automatically uploaded from the mobile app to the iCardia server of our study.

Mobile Health and Remote BP monitoring

All participants randomized to the E2 intervention will have a focused consultation with either a clinical pharmacist or an APN. During this consultation, the pharmacist/APN repeats the BP measurement; reviews the screening assessments; and reviews general principles of BP control including nutrition, exercise, and smoking cessation. BP will be managed according to the current published guidelines available at the time of funding regarding initiation of first-line antihypertensive medications. Patients with BP ≥160/100 mmHg may be started on antihypertensive medications by the provider during the consultation if appropriate.

Post-Acute Care HTN Transition consultation (PACHT-c)

Patients will be recruited before the start of radiotherapy. A blood sample (20 ml) will be taken before radiotherapy and immediately after the 4th radiotherapy session.

They will be followed up annually for 5 years after the end of treatment, to determine whether their cancer has recurred.

A blood sample (20 ml) will be taken prior to radiotherapy

blood sampling before radiotherapy

A blood sample (20 ml) will be taken immediately after the 4th radiotherapy session.

blood sampling after the fourth radiotherapy session

collection of acute toxicity (radiodermatitis)

collection of late toxicity

collection of disease status

40.05 Gy in 15 fractions of 2.67 Gy, one fraction per week, 5 days per week Or 50 Gy in 25 fractions of 2 Gy, one fraction per week, 5 days per week

Radiotherapy - Breast +/- lymph node areas

10 Gy in 4 fractions of 2.5 Gy, one fraction per week, 5 days per week Or 16 Gy in 8 fractions of 2 Gy, one fraction per week, 5 days per week

Radiotherapy - Boost operating bed

The timing of endoscopic intervention for necrotizing pancreatitis is determined based on the degree of encapsulation

In the encapsulation-oriented group, participants undergo EUS-guided drainage of necrotizing pancreatitis when the degree of encapsulation reaches ≥80%, as confirmed by cross-sectional imaging (preferably contrast-enhanced CT). Imaging is repeated every 7-10 days after enrollment to assess encapsulation. Once sufficient encapsulation is observed and the patient presents with symptoms such as infection, abdominal pain, GOO or biliary obstruction, endoscopic drainage is performed. Drainage is typically performed using a lumen-apposing metal stent (LAMS) placed under EUS guidance, often accompanied by placement of an external drain. Step-up therapy, including endoscopic necrosectomy or additional drainage procedures, may be used if symptoms do not improve. If the patient improves with conservative therapy before encapsulation is achieved, drainage may be deferred. Endoscopic/percutaneous interventions should, in principle, be discussed with the expert panel beforehand.

EUS-guided drainage based on the interval from the onset of acute pancreatitis

In the timing-oriented group, participants undergo EUS-guided drainage of necrotizing pancreatitis at 4 to 5 weeks after the onset of acute pancreatitis, regardless of the degree of encapsulation. Drainage is performed only in symptomatic patients who meet predefined clinical criteria, such as signs of infection, significant pain, GOO, or biliary obstruction. Imaging is performed before the procedure. The standard approach involves placing a LAMS under EUS guidance, optionally supplemented by external drains. If symptoms do not improve, step-up interventions such as endoscopic necrosectomy, percutaneous drainage may be considered. If inflammation and symptoms improve with conservative treatment (e.g., antibiotics), EUS-guided drainage may be omitted. Conversely, even before 4-5 weeks from onset, early drainage is allowed if conservative treatment is deemed insufficient by the attending physician. In principle, intervention decisions should be discussed with the expert panel.

Department of Gastroenterology, The University of Tokyo Hospit

Department of Gastroenterology, Graduate School of Medicine, J

Third Department of Internal Medicine, University of Toyama

Participants will undergo 3 experimental conditions in random order at week of gestation 16 and 35 (experimental phases 1 and 2): pre-meal exercise, post-meal exercise, and non-exercise meal.

Pre-meal exercise: 1º milkshake intake + 2º exercise test

Post-meal exercise: 1º exercise test + 2º milkshake intake

Non-exercise meal: Only milkshake intake

Exercise and meal testing (acute stimuli)

Participants will undergo 3 experimental conditions in random order after recruitment (experimental phase 1): pre-meal exercise, post-meal exercise, and non-exercise meal.

Participants will perform four exercises: squat, knee extension, leg press, and lat pulldown at 80% of 1-RM determined during a previous visit.

Participants will perform three sets of eight repetitions, with a 90-120 second rest between sets, with a fourth set performed to failure. All resistance exercise will be performed on pneumatic resistance devices (Keiser Sports Health Equipment, Fresno, CA).

Acute Resistance Exercise

Patients in this arm will receive PEACE Intervention

The Paramedic Evaluation for Acute COPD Exacerbation (PEACE) program is a mobile integrated health initiative that aims to evaluate and treat COPD exacerbation in the home. The goal of the intervention is to expedite the recognition and treatment of COPD exacerbation as well as For this intervention, ambulatory teams can refer patients for PEACE visits when a patient has been identified as suffering from symptoms consistent with COPD exacerbation. Once a visit is requested via electronic health record order, a community paramedic presents to the patient's home within 2 hours, evaluates the patient using mobile diagnostic testing, and initiates pharmacological therapies protocolized by the pulmonary team. A standardized clinical approach and documentation strategy is used including a focused history and physical exam, venous blood gas, trending pulse-oximetry, and mobile x-ray. The community paramedic is supervised in real-time by an emergency physician to establish a care plan and di

Paramedic Evaluation for acute COPD Exacerbation

This study is a prospective, interventional clinical trial recruiting patients with blast-phase chronic myeloid leukemia from the Stem Cell Transplantation Center of the Institute of Hematology \& Blood Diseases Hospital, Chinese Academy of Medical Sciences, with an anticipated enrollment of 40 cases. Enrolled patients are scheduled to receive a reduced-toxicity conditioning regimen containing thiotepa, melphalan, and fludarabine for allogeneic hematopoietic stem cell transplantation. Thiotepa 5mg/kg on days -8 and -7, melphalan 60mg/m2 on days -5 and -4, Flu 30mg/m2 from day -6 to day -2.

Enrolled patients with blast-phase chronic myeloid leukemia received a reduced-toxicity conditioning regimen containing thiotepa, melphalan, and fludarabine prior to undergoing allogeneic hematopoie

Institute of Hematology & Blood Diseases Hospital, China

individuals 18 years of age and older who are implanted with a VNS device (standard of care), which consists of patients who have been diagnosed with drug resistant epilepsy or major depressive disorder.

Frequency order: F1=1Hz, F2=10Hz, F3=30Hz, period 1,2 and 3 respectively

Duty cycle: At Visit 1, while the frequencies are being changed over Period 1, 2, and 3, duty cycle will be held constant at the participant's randomly assigned first duty cycle setting. At Visit 2, duty cycle will be held constant at the participant's randomly assigned second duty cycle setting. At Visit 2 the participant will receive whichever duty cycle they were not randomly assigned at Visit 1. Therefore, by completing the combination of three frequencies at two duty cycles, each participant will have received all six possible VNS parameter combinations over the two study visits. Chronic period: The VNS setting for the Chronic Period in between Visit 1 and Visit 2 will be the same settings as tested during Visit 1 Period 3. Since Visit 1 Period 3 settings were already randomly assigned to each participant, another randomization for the chronic period is not needed.

Vagus nerve stimulation device: acute and chronic administration of investigational vagus nerve stimulation parameters

individuals 18 years of age and older who are implanted with a VNS device (standard of care), which consists of patients who have been diagnosed with drug resistant epilepsy or major depressive disorder.

Frequency order: F2=10Hz, F3=30Hz, F1=1Hz, period 1,2 and 3 respectively

individuals 18 years of age and older who are implanted with a VNS device (standard of care), which consists of patients who have been diagnosed with drug resistant epilepsy or major depressive disorder.

Frequency order: F3=30Hz, F1=1Hz, F2=10Hz, period 1,2 and 3 respectively

individuals 18 years of age and older who are implanted with a VNS device (standard of care), which consists of patients who have been diagnosed with drug resistant epilepsy or major depressive disorder.

Frequency order: F1=1Hz, F3=30Hz, F2=10Hz, period 1,2 and 3 respectively

individuals 18 years of age and older who are implanted with a VNS device (standard of care), which consists of patients who have been diagnosed with drug resistant epilepsy or major depressive disorder.

Frequency order: F2=10Hz, F1=1Hz, F3=30Hz, period 1,2 and 3 respectively

individuals 18 years of age and older who are implanted with a VNS device (standard of care), which consists of patients who have been diagnosed with drug resistant epilepsy or major depressive disorder.

Frequency order: F3=30Hz, F2=10Hz, F1=1Hz, period 1,2 and 3 respectively

Kathryn Vera

This arm consist of only healthy participants (age (+/- 3 years) and sex matched to the COPD group), which will undergo three study visits

1\) a 5-minute warm-up, 2) 4 minutes at 60% of the maximal workload (determined on Study Day 1), 3) 2 minutes active break at 15 watt, 4) 4 minutes at maximal workload.

Acute exercise bout on visit 2 and 3

This arm consist of only COPD patients, which will undergo three study visits

For participants randomized to ANH, the volume of blood to be removed will be calculated using an established formula, based on preoperative hemoglobin, target hemoglobin after hemodilution, and the patient's estimated blood volume.

Acute Normovolemic Hemodilution/ANH

Dennis Chi, MD

In Group 1, participants will receive the usual standard of care, during your emergency room visit, provided by the Acute Cancer Care Center (ACCC) treating doctor who will address symptoms and other medical problems that brought the participant to the emergency room.

In Group 1, participants will receive the usual standard of care by an emergency care physician not trained in palliative care.

Standard of Care (Acute Cancer Care Center)

In Group 2, participants will receive the above usual standard of care plus goals of care (GOC) intervention.

In Group 2, participants will receive standard of care plus palliative care intervention by an emergency care physician trained in palliative care.

Standard of Care (Goals of Care)

Ahmed Elsayem, MD,MPH

Standard Leukemia Care

Collaborative care from Palliative Care and Leukemia will be given

급성 간헐적 저산소증, 가짜 급성 간헐적 저산소증

완화 치료, 표준 백혈병 치료

고혈압 교육 비디오, 시각적 심초음파 이미지 클립, 모바일 건강 및 원격 혈압 모니터링, 급성기 치료 후 고혈압 전환 상담(PACHT-c)

방사선 치료 전 혈액 채취, 4회 방사선 치료 후 혈액 채취, 급성 독성(방사선 피부염) 수집, 만성 독성 수집, 질병 상태 수집, 방사선 치료 - 유방 및/또는 림프절 부위, 방사선 치료 - 추가 조사 수술대

괴사성 췌장염의 내시경적 중재 시기는 캡슐화 정도에 따라 결정되며, EUS 유도 배액은 급성 췌장염 발병 시점부터의 간격에 따라 결정됩니다.

운동 및 식사 검사(급성 자극)

급성 저항 운동

급성 COPD 악화에 대한 구급대원 평가

급성기 만성 골수성 백혈병을 앓고 있는 등록된 환자들은 동종 조혈모세포 이식을 받기 전에 티오테파, 멜팔란 및 플루다라빈을 함유한 저독성 컨디셔닝 요법을 받았습니다.

미주신경 자극 장치: 연구용 미주신경 자극 매개변수의 급성 및 만성 투여

2차, 3차 방문 시 급성 운동

급성 정상혈량 혈액희석/ANH

표준 치료(급성 암 치료 센터), 표준 치료(치료 목표)

표준 백혈병 치료, 완화 치료