The intervention aims to terminate pathological brain oscillations (i.e. epileptiform activity) in patients.

Intersection short-pulse (ISP) stimulation

Principal Investigator

Twice-weekly hemodialysis with incremental crossover to thrice-weekly hemodialysis as indicated

50% of the eligible participants will be assigned to twice-weekly hemodialysis for up to 12 months with incremental crossover to thrice-weekly hemodialysis as indicated.

Twice-weekly hemodialysis with incremental crossover to thrice-weekly schedule

Outright thrice-weekly hemodialysis without option to switch to less frequent dialysis schedule

50% of the eligible participants will be assigned to outright thrice-weekly hemodialysis, which will be continuation of the initial thrice-weekly schedule during the run-in period, without the option to switch to less frequent dialysis schedule representing the standard of care.

Thrice-Weekly Hemodialysis

Kamyar Kalantar-Zadeh, MD PhD

Jeffrey A Kraut, MD

David Geller, MD

Susan Crowley, MD

Mark L Unruh, MD

David S Goldfarb, MD

Csaba P Kovesdy, MD

After keratoconus diagnosis the patient won't be assigned to intervention

abstention

After keratoconus diagnosis the patient was assigned to cross linking surgery or intra corneal ring surgery

After keratoconus diagnosis the patient was assigned to surgery

cross-linking surgery or intra corneal ring

Vincent DAIEN, Pr

Vincent Daien, Pr

Fanny Babeau, Dr

Pierre Fournié, Pr

David Touboul, Pr

Preoperative measurements from the OCT are used to assist the calculation in deciding the laser depth settings for smoothing the anterior corneal surface and removing any present opacities. The surgeon uses the OCT data to plan treatment parameters while preserving at least 360 microns of residual corneal stroma using a phototherapeutic keratectomy procedure. After the laser procedure, adjunctive MMC or saline solution will be applied to the cornea in accordance with the group to which the treated eye is randomized. The CXL procedure is then performed following the FDA-approved CXL regimen by Avedro, Inc.

Laser Custom Corneal Collagen Cross-Linking

Denzil Romfh, OD

Humberto Martinez, COT

On the basis of standard treatment, a combined treatment plan of TCM universal treatment and syndrome-specific treatment was given.

TCM universal treatment plan:

(Intensive treatment) Chuanzhi Tongluo Capsules (Lunan Pharmaceutical), 4 capsules each time, orally, 3 times a day; administration from day 1 to day 14 of the disease.

(Sequential treatment) Chuanzhi Tongluo Capsules (Lunan Pharmaceutical), 2 capsules each time, orally, 3 times a day; administration from day 15 to day 365.

TCM decoction: Individualized herbal decoction based on TCM diagnosis (four diagnostic methods), administered for 14 days during intensive phase.

4 capsules each time, orally, 3 times a day; administration from day 1 to day 14 of the disease.

(Intensive treatment) Chuanzhi Tongluo Capsules

2 capsules each time, orally, 3 times a day; administration from day 15 to day 365.

(Sequential treatment) Chuanzhi Tongluo Capsules

Individualized herbal decoction based on TCM diagnosis (four diagnostic methods), administered for 14 days during intensive phase.

TCM Syndrome Differentiation Decoction

Guideline-based treatment for cerebral infarction with diabetes: aspirin (100 mg/day) + clopidogrel (75 mg/day) + atorvastatin (20 mg/day) + metformin (500 mg bid). Other antiplatelet/antidiabetic drugs may be added per clinician discretion.

Combination therapy including: 1. Antiplatelet: aspirin 100 mg/day + clopidogrel 75 mg/day. 2. Lipid-lowering: atorvastatin 20 mg/day. 3. Antidiabetic: metformin 500 mg bid (max 2000 mg/day). \*Doses may be adjusted per local guidelines or patient tolerance.

Standard Treatment (Guideline-Based)

Guangzhou University of Traditional Chinese Medicine

All subjects will be assigned to the XL1 Coil treatment group.

The surgeon verifies the intestinal diameter and selects the appropriate device diameter size. The device is introduced into the lumen of the intestine and advanced about 5-10cm. The surgeon uses 4-0 chromic sutures placed in the seromuscular layer to secure the XL1 Coil within the intestine. The surgeon places metal clips on proximal and distal sutures and in the mesentery adjacent to the XL1 Coil ends to mark the location for radiologic evaluation. The surgeon releases the XL1 Coil and closes the enterotomy.

Distraction Enterogenesis in Adult Patients with Short Bowel Syndrome

Shweta Namjoshi, MD

Matthew Lin, MD

Anisha Abreo

Joseph Forrester, MD

Clarivet Torres, MD

Meghan Fitzgerald

Mark Puder, MD

Beth Cobb

Michael Helmrath, MD

Paul Wales, MD

다운증후군 아동을 대상으로 2개월간 드럼 레슨이 자기 통제력과 타이밍 기술 향상에 미치는 영향을 연구하는 시험입니다.

Experimental group will receive the drumming lesson intervention between baseline and testing approximately 2 to 3 months later, so the effects of the intervention can be assessed in the lab measures.

Drumming lessons consisting of how to use hands to drum on djembe drum, using alternating hands to drum, drumming to a metronome and to music.

2 months of drumming lessons given by a professional drummer with extensive experience working with children with Down syndrome

Children in the Control condition will receive drumming lessons only after they have completed lab baseline and testing measures, about 2 to 3 months later.

Receiving lessons after the two lab visits should still offer any possible positive effects to participants while still allowing us to compare the Control group children's behaviors to those of the Experimental group.

Lessons after measurement

실험군은 기준선과 시험 사이에 약 2~3개월 후에 드럼 연주 레슨 개입을 받게 되므로, 실험실 측정을 통해 개입의 효과를 평가할 수 있습니다.

다운증후군 아동을 대상으로 광범위한 경험을 쌓은 전문 드러머가 제공하는 2개월간의 드럼 레슨

통제 조건에 있는 어린이는 실험실 기준선과 시험 측정을 완료한 후 약 2~3개월 후에만 드럼 레슨을 받게 됩니다.

측정 후의 교훈

Caroline Danforth, MS

Alison Rubin, BA

Amy Needham, PhD

Miriam Lense, PhD

드럼 레슨이 다운증후군 아동에게 미치는 영향

Subjects who meet the inclusion criteria and provide informed consent will be randomized to receive UVA irradiation with 15-second off-on cycling for either 18 minutes or 24 minutes

Corneal cross-linking involves the following steps:

* applying riboflavin (Vitamin B2 eye drops) to the eye, then
* exposing the eye to ultraviolet (UV-A) light

Epi-ON corneal cross-linking

QC meetings with PCPs in the intervention group to reflect on their CRC screening practices and implement changes in sequential Plan-Do-Check-Act (PDCA) quality improvement cycles. In the first meeting, they will be given evidence summaries on CRC screening, a decision support leaflet designed to help them discuss CRC screening with their patients and a patient decision aid in form of a brochure (Plan-Do). PCPs will receive sample FIT kits recommended for organized screening programs and will be encouraged to offer FIT tests if they have not done so before. In the second QC meeting, PCPs will be shown how to fill out the patient data collection form (Check). The third QC meeting will take place after data collection and analysis. Researchers will present their results to the QCs and PCPs will discuss subsequent steps to improve care (Act). The QC will then repeat one PDCA cycle. The control group will receive the same intervention one year later.

Multilevel training intervention (intervention group)

Participants in the control group will receive the intervention after 12 months, cross-over design

The control group will undergo a crossover and receive the same intervention one year after the intervention group. QC meetings with PCPs in the intervention group to reflect on their CRC screening practices and implement changes in sequential Plan-Do-Check-Act (PDCA) quality improvement cycles. In the first meeting, they will be given evidence summaries on CRC screening, a decision support leaflet designed to help them discuss CRC screening with their patients and a patient decision aid in form of a brochure (Plan-Do). PCPs will receive sample FIT kits recommended for organized screening programs and will be encouraged to offer FIT tests if they have not done so before. In the second QC meeting, PCPs will be shown how to fill out the patient data collection form (Check). The third QC meeting will take place after data collection and analysis. Researchers will present their results to the QCs and PCPs will discuss subsequent steps to improve care (Act).

Multilevel training intervention (control group with crossover)

Corneal cross-linking involves the following steps:

* applying riboflavin (Vitamin B2 eye drops) to the eye, then
* exposing the eye to ultraviolet (UV-A) light for 20 minutes.

Epi-ON corneal cross-linking (CXL)

JYP0322, 150 mg, administered orally three times daily (tid) after meals; sample size (N) = 60.

JYP0322 tablets

Randomization to either JYP0322 or platinum-based doublet-chemotherapy on Day 1 of every 21d cycle in a 2:1 (JYP0322: platinum-based doublet-chemotherapy) ratio

Pemetrexed injection

Once subjects on the platinum-based doublet chemotherapy arm are determined to have objective radiological progression according to RECIST 1.1 by the investigator and confirmed by BICR, they will be given the opportunity to begin treatment with JYP0322 150mg tid. These subjects may continue treatment with JYP0322 if they are continuing to show clinical benefit until disease progression as judged by the investigator.

Cross-over to JYP0322

결절성 경화증 환자 어린이와 청소년을 대상으로 Basimglurant의 발작 조절 효과를 비교하는 시험입니다.

교차 단펄스(ISP) 자극

3주 일정으로 점진적으로 교차되는 2주 1회 혈액투석, 3주 1회 혈액투석

교차결합 수술 또는 각막내 링, 금욕

레이저 맞춤형 각막 콜라겐 교차 결합

(집중치료) 천지동락캡슐, 표준치료(지침기반), (순차치료) 천지동락캡슐, 중의학 증후군 감별탕

단장증후군 성인 환자의 분산성 장내생성

드럼 레슨이 다운증후군 아동에게 미치는 영향

Epi-ON 각막 교차결합

다단계 훈련 개입(개입군), 다단계 훈련 개입(교차 대조군)

Epi-ON 각막 교차 결합(CXL)

페메트렉세드 주사제, JYP0322와의 교차제, JYP0322 정제

TSC를 앓고 있는 어린이, 청소년 및 청년 성인의 Basimglurant(NOE-101)