뒤셴 근이영양증 청소년을 위한 게임 기반 작업 치료가 삶의 질과 감정 건강에 미치는 영향을 기존 방법과 비교하는 연구입니다.

Gamified occupational therapy programme group

Gamified occupational therapy program for the experimental group and classical occupational therapy program for the control group, which will be applied to both groups for eight weeks

Gamified occupational therapy programme

Classic occupational therapy programme

게임화된 작업 치료 프로그램 그룹

게임화된 작업 치료 프로그램

고전적인 작업 치료 프로그램

Duchenne muscular dystrophy occurs mostly in boys and very rarely in girls. Girls are usually carriers.

Başak Çağla Arslan, Master's Degree

듀센 근디스트로피를 앓는 청소년을 위한 게임화된 작업 치료

MS history and MS treatments and Expanded Disability Status Scale (EDSS) score will be recorded

Clinical assessment

Information processing speed (IPS) Working memory (WM) Executive functions (EF) Episodic memory (EM) Premorbid intelligence quotient (IQ) Multidomain or complex task

Classical cognitive evaluation of several domains:

Ecological evaluation

Patent reported outcomes (PRO's) : Beck Depression Inventory (BDI), European Quality of Life-5 Dimensions (EQ-5D-5L) for Health-Related Quality of Life (HRQOL), Multiple Sclerosis Impact Scale-29 Items (MSIS-29), French version of the Modified Fatigue Impact Scale (EMISEP) and State trait anxiety inventory (STAI).

Subjective cognitive deficits: Perceived Deficits Questionnaire (PDQ) and Cognitive Activities Questionnaire (DCAQ)

Patent reported outcomes (PRO's)

The Cognitive rehabilitation (CR) consists of weekly 45 minutes online individual session with the unblinded Speech Therapist.

Telerehabilitation : active procedure

Once per week over a 12-week period completed by daily online exercises performed by the patient 4 days a week.

Telerehabilitation : comparator procedure

Classical rehabilitation program (stretching, strenght, balance and coordination exercise) for fifty minutes.

Muscle strengthening in all four extremities; strengthening of trunk and abdominal muscles; providing and maintaining joint range of motion; independent and safe standing, turning, and stepping; able to walk alone on flat ground and on different surfaces (such as sloping-handicapped-soil-stone-sand-grass-rough-stepped)

classical rehabilitation

Deep sensory asisted rehabilitation program (stretching, strenght, balance and coordination and deep sensory exercises) for fifty minutes.

A new PTR plan called "deep sensory assisted rehabilitation" was created: it was aimed to develop a sensory and deep sense in the adult age group by making use of sensory integration exercises, which are mostly applied in the childhood age group. Whether these exercises are effective on walking and balance will be evaluated. Patients will be dressed in a vest with an equally distributed weight of 4-6 kg according to their weight, and exercises will be done while walking and standing.

\- the so-called "deep sensory pathway"; The patients will be given standing and walking exercises on sand and stone floors, soft floors made of sponge, hard plastic floors with different sizes of grooves and shapes, and hot-cold floors formed by placing hot packs and cold packs.

Deep sensory assisted rehabilitation

After peritomy, coagulation, and the application of 0.04% mitomycin C (as in a trabeculectomy or any filtration surgery), a scleral tunnel is created 3 mm from the limbus using a 1-mm scalpel designed for this purpose, followed by a 25G needle, which is inserted into the eye parallel to the iris. Next, the Preserflo is inserted into this tunnel, away from the cornea and the iris. The outflow of aqueous humor through the Preserflo is tested by injecting BSS into the anterior chamber. The peritomy is then closed (as in a trabeculectomy).

Classical surgery

A 9-0 Ethilon suture is inserted into the distal end of the Preserflo to partially occlude the outflow of aqueous humor through this drain, thereby reducing the risk of postoperative hypotony. The other end of this suture is attached to the cornea, forming a loop (which will allow it to be removed later). Next, the Preserflo and the suture are covered with the Tenon's capsule and the conjunctiva, as in the standard technique.

Intraluminal suture

All participants will first receive a massage and then be manipulated with the spinal manipulation technique.

All participants will first receive a massage to relax the muscles and then be manipulated with a spinal manipulation technique.

manipulation with classical massage and spinal manipulation technique

Only women were included to exclude the effects of different hormonal structures and gender on pain.

Hippocampal-Sparing Whole-Brain Radiotherapy + Simultaneous Integrated Boost to Brain Metastases + O

Hippocampus-Protective Radiotherapy Combined With Osimertinib for Symptomatic Brain Metastases in EGFR-classic Mutated Lung Cancer

Tianjin Medical University Cancer Institute and Hospital

• Experimental group, which will follow a structured palliative care pathway (specific intervention defined in the protocol) based on the frailties identified at baseline PROMs (defined by cut-off).

Symptoms/needs domains are defined according to protocol-specified cut-offs, followed by the activation of a tailored intervention based on structured checklists targeting the reported symptoms/needs.

Structured Palliative Care

• Control group, which will undergo standard unstructured palliative care (based on PROMs as usual, but without cut-off or interventions' checklists)

Multidisciplinary palliative care interventions are delivered according to usual clinical practice, without activation based on predefined cut-offs or structured algorithms.

듀센 근디스트로피를 앓는 청소년을 위한 게임화된 작업 치료

임상 평가, 여러 도메인의 고전적 인지 평가: 생태학적 평가, 특허 보고 결과(PRO), 원격 재활: 활성 절차, 원격 재활: 비교 절차

심층 감각 보조 재활, 고전적 재활

고전적 외과 수술, 내강 내 봉합

고전적 마사지와 척추 조작 기술을 이용한 조작

EGFR 고전적 변이 폐암의 증상성 뇌전이에 대한 해마 보존 전뇌 방사선 치료 + 동시 통합 부스트 요법 + O, 해마 보호 방사선 치료와 오시머티닙 병용 요법

구조화된 완화 치료, 고전적 완화 치료