MS history and MS treatments and Expanded Disability Status Scale (EDSS) score will be recorded

Clinical assessment

Information processing speed (IPS) Working memory (WM) Executive functions (EF) Episodic memory (EM) Premorbid intelligence quotient (IQ) Multidomain or complex task

Classical cognitive evaluation of several domains:

Ecological evaluation

Patent reported outcomes (PRO's) : Beck Depression Inventory (BDI), European Quality of Life-5 Dimensions (EQ-5D-5L) for Health-Related Quality of Life (HRQOL), Multiple Sclerosis Impact Scale-29 Items (MSIS-29), French version of the Modified Fatigue Impact Scale (EMISEP) and State trait anxiety inventory (STAI).

Subjective cognitive deficits: Perceived Deficits Questionnaire (PDQ) and Cognitive Activities Questionnaire (DCAQ)

Patent reported outcomes (PRO's)

The Cognitive rehabilitation (CR) consists of weekly 45 minutes online individual session with the unblinded Speech Therapist.

Telerehabilitation : active procedure

Once per week over a 12-week period completed by daily online exercises performed by the patient 4 days a week.

Telerehabilitation : comparator procedure

Patients receive atezolizumab IV over 30-60 minutes on day 1, bevacizumab IV over 30-90 minutes on day 1, gemcitabine IV over 30 minutes on days 1 and 8, and cisplatin IV on days 1 and 8. Cycles repeats every 21 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT or MRI throughout the trial. Patients undergo blood specimen collection on study.

Atezolizumab

Bevacizumab

Biospecimen Collection

Cisplatin

Computed Tomography

Conventional Magnetic Resonance Imaging

Gemcitabine Hydrochloride

Patients receive atezolizumab IV over 30-60 minutes on day 1, and gemcitabine IV over 30 minutes and cisplatin IV on days 1 and 8. Cycles repeats every 21 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT or magnetic resonance imaging MRI throughout the trial. Patients undergo blood specimen collection on study.

All participants will first receive a massage and then be manipulated with the spinal manipulation technique.

All participants will first receive a massage to relax the muscles and then be manipulated with a spinal manipulation technique.

manipulation with classical massage and spinal manipulation technique

Only women were included to exclude the effects of different hormonal structures and gender on pain.

임상 평가, 여러 도메인의 고전적 인지 평가: 생태학적 평가, 특허 보고 결과(PRO), 원격 재활: 활성 절차, 원격 재활: 비교 절차

아테졸리주맙, 베바시주맙, 생체 검체 채취, 시스플라틴, 컴퓨터 단층촬영, 고전적 자기공명영상, 젬시타빈 염산염

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