Polina Zmijewski, MD

Patients receive oncolytic measles virus encoding thyroidal sodium iodide symporter IP over 30 minutes on day 1 of cycle 1 and MV-NIS infected MSC (if MSC are not available, MV-NIS may be given alone) IP over 30 minutes of subsequent cycles. Treatment repeats every 28 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.

Additionally, patients undergo ECHO or MUGA prior to registration and blood sample collection, chest X-ray, SPECT/CT, CT or MRI throughout the study.

Laboratory Biomarker Analysis

Mesenchymal Stem Cell Transplantation

Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter

Echocardiography

Multigated Acquisition Scan

Biospecimen Collection

Chest Radiography

Single Photon Tomography and Computed Tomography Scan

Computed Tomography

Magnetic Resonance Imaging

Participants undergo adenoma removal guided by PTS imaging, with deliberate preservation of the NIR-autofluorescent rim of normal parathyroid tissue.

FDA-cleared imager (e.g., Fluobeam LX/PTeye) providing real-time autofluorescence to identify parathyroid tissue during surgery; no dye or radiation.

Near-Infrared Parathyroid Tissue Sensor Imaging (PTS)

Surgical excision of adenoma while leaving the NIRAF-positive rim of normal parathyroid tissue in situ; minimal defatting to ensure perfusion.

Rim-Preservation Technique

Participants undergo PTS-guided en-bloc excision of the adenoma plus its NIR-positive rim; parathyroid autotransplantation performed when indicated.

Surgical excision of adenoma together with the surrounding NIRAF-positive rim; autotransplant fragment if \< 2 normal glands remain in neck.

En-bloc Resection Technique

Bo Wang Porfessor, MD

Bo Wang MD, Principal Investigator

124I PET/CT scan after preparation with human recombinant TSH

intramuscular injection administered once/day for 2 consecutive days at Week 3; then once annually for subjects who meet criteria.

Thyrogen

therapeutic dose administered orally to treat thyroid cancer at Week 8. 5-7 days later, the post-treatment I-131 Whole Body scan w/ SPECT is performed; then administered once annually, if the patient needs to be re-treated

I-131

one capsule ingested orally once at Week 3, and Week 8; then administered once annually to subjects who meet criteria.

I-124

124I PET/CT scan after preparation with thyroid hormone withdrawal

withdrawal of thyroid hormone during weeks 4 through 8

Thyroid hormone withdrawal

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Patients receive oncolytic measles virus encoding thyroidal sodium iodide symporter IP over 30 minutes on day 1. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Quality-of-Life Assessment

Patients receive pegylated liposomal doxorubicin hydrochloride IV over 1 hour on day 1, or gemcitabine hydrochloride IV over 30 minutes on days 1, 8, and 15, or topotecan hydrochloride IV over 30 minutes on days 1, 8, and 15, or paclitaxel IV over 1 hour on days 1, 8, and 15. Patients may also receive bevacizumab IV over 30-90 minutes on days 1 and 15 with pegylated liposomal doxorubicin hydrochloride, topotecan hydrochloride, or paclitaxel. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Bevacizumab

Gemcitabine Hydrochloride

Paclitaxel

Pegylated Liposomal Doxorubicin Hydrochloride

Topotecan Hydrochloride

All enrolled patients for thyroid surgery, once the thyroid gland is removed the device will be used to identify the parathyroid glands.

Parathyroid auto-fluorescence imaging

For a select group of patients when deemed necessary by the surgeon, and when one or more parathyroid gland appear to be de vascularized ICG will be administered, A dosage of 5 mg will be injected into a peripheral IV line, followed by fluorescence imaging to determine the perfusion status of the gland.

Indocyanine green

Gluten Free Diet in patients with Hashimoto's Hypothyroidism

부갑상선 동종이식

근적외선 부갑상선 조직 센서 영상(PTS), 림 보존 기술, 일괄 절제 기술

티로겐, I-131, I-124, 갑상선 호르몬 금단

베바시주맙, 젬시타빈 염산염, 실험실 바이오마커 분석, 갑상선 요오드화나트륨 심포터(Symporter)를 암호화하는 용균성 홍역 바이러스, 파클리탁셀, 페길화 리포좀 독소루비신 염산염, 삶의 질 평가, 토포테칸 염산염

부갑상선 자가형광 영상, 인도시아닌 그린

하시모토 갑상선 기능 저하증 환자의 글루텐 프리 식단