Polina Zmijewski, MD

Patients receive oncolytic measles virus encoding thyroidal sodium iodide symporter IP over 30 minutes on day 1 of cycle 1 and MV-NIS infected MSC (if MSC are not available, MV-NIS may be given alone) IP over 30 minutes of subsequent cycles. Treatment repeats every 28 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.

Additionally, patients undergo ECHO or MUGA prior to registration and blood sample collection, chest X-ray, SPECT/CT, CT or MRI throughout the study.

Laboratory Biomarker Analysis

Mesenchymal Stem Cell Transplantation

Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter

Echocardiography

Multigated Acquisition Scan

Biospecimen Collection

Chest Radiography

Single Photon Tomography and Computed Tomography Scan

Computed Tomography

Magnetic Resonance Imaging

Parathyroid Allotransplant to treat hypoparathyroidism

Parathyroid Allotransplant

Crystal Loucel, MPH, MS, RN

Participants undergo adenoma removal guided by PTS imaging, with deliberate preservation of the NIR-autofluorescent rim of normal parathyroid tissue.

FDA-cleared imager (e.g., Fluobeam LX/PTeye) providing real-time autofluorescence to identify parathyroid tissue during surgery; no dye or radiation.

Near-Infrared Parathyroid Tissue Sensor Imaging (PTS)

Surgical excision of adenoma while leaving the NIRAF-positive rim of normal parathyroid tissue in situ; minimal defatting to ensure perfusion.

Rim-Preservation Technique

Participants undergo PTS-guided en-bloc excision of the adenoma plus its NIR-positive rim; parathyroid autotransplantation performed when indicated.

Surgical excision of adenoma together with the surrounding NIRAF-positive rim; autotransplant fragment if \< 2 normal glands remain in neck.

En-bloc Resection Technique

Bo Wang Porfessor, MD

Bo Wang MD, Principal Investigator

레어노트에 환자 모임 등록

회원 모집 중

희귀난치성 질환 거짓부갑상선기능저하증 환우회입니다. 환자·보호자 분들과 소통하며 정보 공유를 하는 공간입니다.

<dl class="v3-editor-content-dictionary">
<dt>거짓 부갑상선기능저하증 이란?</dt>
<dd>거짓 부갑상선기능저하증은 부갑상선호르몬 수치는 정상이나 호르몬에 대한 부적절한 반응으로 특징되는 유전 질환입니다. 이러한 반응은 뼈 성장에 영향을 미칠 수 있습니다. X-염색체 연관 혹은 상염색체 우성 유전양식으로 유전됩니다.</dd>
<dd> </dd>
<dd><a href="rarenote://MedicalNewsDetail?id=a30039d0-4a44-44da-b6f1-d1a819dc0100">질환에 대해 더 알아보기</a></dd>
</dl>
'거짓부갑상선기능저하증 환우회' 는 국내 거짓 부갑상선기능저하증 환자와 보호자들을 위한 커뮤니티로, 2024년에 설립되었어요.
네이버 카페로 운영되며, 질환과 관련된 정보를 교류하고 소통할 수 있는 공간입니다.

임상시험 현황

부갑상선 동종이식

부갑상선 동종이식

근적외선 부갑상선 조직 센서 영상(PTS), 림 보존 기술, 일괄 절제 기술

환자 모임 정보