Patients without a primary care physician within the UPHS health system will receive direct outreach from the study team to invite them to schedule a visit with a lipid specialist for a formal evaluation of FH.

All eligible patients will be informed that they have been identified by the FIND FH tool as potentially having familial hypercholesterolemia. All patients will be invited to schedule a telehealth appointment with a lipid specialist for a formal evaluation for FH.

Inviting patients to complete a telehealth appointment with a lipid specialist for an FH evaluation

For patients with a primary care physician within the UPHS health system, their primary care physicians will be asked to review and sign physician referrals to a lipid specialist and invite patients to schedule a visit with a lipid specialist for a formal evaluation of FH.

For patients with a Penn PCP, we are testing a centralized referral mechanism to increase the number of referrals to preventive cardiology (default/opt out referrals)

For default/opt out: PCPs will receive a pended order for a referral for their patient to see a lipid specialist for a formal FH evaluation. Not interacting with the pended order or accepting the pended order will indicate that the referral to a lipid specialist should be placed.

Testing centralized referral mechanism for PCPs

급성 관상동맥 증후군으로 입원한 환자에게 유전자 검사를 통해 가족성 고콜레스테롤혈증을 진단하고 치료에 미치는 영향을 평가하는 시험입니다.

Those admitted in the first 6 months of the study that meet the inclusion criteria. Patients will be treated according to the normal standard of care for acute coronary syndrome.

Those admitted between 6-18 months of the study meeting the inclusion criteria. Saliva samples will be collected for DNA testing.

Next-generation targeted sequencing assay to identify DNA variants in genes known to cause Familial Hypercholesterolemia

Research-based genetic test for Familial Hypercholesterolemia

연구 시작 후 6개월 이내에 입원하여 포함 기준을 충족하는 환자를 대상으로 합니다. 환자들은 급성 관상동맥 증후군에 대한 일반적인 표준 치료에 따라 치료받을 것입니다.

연구 시작 후 6~18개월 사이에 참여 기준을 충족하는 사람들을 대상으로 타액 샘플을 채취하여 DNA 검사를 실시할 예정입니다.

일차 진료의를 위한 중앙 집중식 의뢰 체계 테스트, 환자들이 가족성 고콜레스테롤혈증(FH) 평가를 위해 지질 전문의와의 원격 진료 예약을 완료하도록 안내

심장 집중 치료실 기반의 고콜레스테롤혈증 신속 평가 및 치료 발전